Fig. Jiang et al. Using nanoparticles in targeted drug delivery provides exciting opportunities for much more safety and effective cancer treatment. Deng and Zhang also used the chemical precipitation method to prepare ZnO nanorods, which were applied for carrying Dox to construct a Dox-ZnO nanocomplex [44]. DOX-ZnO/PEG nanocomposites not only enhanced the intracellular accumulation of DOX but also presented a concentration-dependent inhibition on cervical cancer HeLa cell proliferation. Keywords: ZnO, nanoparticles, MO CVD, morphology. Campus Kumaun University, Almora 263601, India . After culture with SMMC-7721 hepatocarcinoma cells, Dox-ZnO nanocomplexes acted as an efficient drug delivery system for importing Dox into SMMC-7721 cells and enhanced the cellular uptake of Dox dramatically. XRD spectra of zinc oxide (a) nanotriangles, (b) spherical nanoparticles, and (c) nanorods. Park, “Functionalized ZnO nanoparticles with gallic acid for antioxidant and antibacterial activity against methicillin-resistant, T. Ohira and O. Yamamoto, “Correlation between antibacterial activity and crystallite size on ceramics,”, S. Sarwar, A. Ali, M. Pal, and P. Chakrabarti, “Zinc oxide nanoparticles provide anti-cholera activity by disrupting the interaction of cholera toxin with the human GM1 receptor,”, S. N. Seclen, M. E. Rosas, A. J. Arias, and C. A. Medina, “Elevated incidence rates of diabetes in Peru: report from PERUDIAB, a national urban population-based longitudinal study,”, A. Nazarizadeh and S. Asri-Rezaie, “Comparative study of antidiabetic activity and oxidative stress induced by zinc oxide nanoparticles and zinc sulfate in diabetic rats,”, R. D. Umrani and K. M. Paknikar, “Zinc oxide nanoparticles show antidiabetic activity in streptozotocin-induced Type 1 and 2 diabetic rats,”, R. Malizia, A. Scorsone, P. D’Angelo, C. Lo Pinto, L. Pitrolo, and C. Giordano, “Zinc deficiency and cell-mediated and humoral autoimmunity of insulin-dependent diabetes in thalassemic subjects,”, R. Kitture, K. Chordiya, S. Gaware et al., “ZnO nanoparticles-red sandalwood conjugate: a promising anti-diabetic agent,”, J. Hussein, M. El-Banna, T. A. Razik, and M. E. El-Naggar, “Biocompatible zinc oxide nanocrystals stabilized via hydroxyethyl cellulose for mitigation of diabetic complications,”, A. Bayrami, S. Parvinroo, A. Habibi-Yangjeh, and S. Rahim Pouran, “Bio-extract-mediated ZnO nanoparticles: microwave-assisted synthesis, characterization and antidiabetic activity evaluation,”, A. Amiri, R. A. F. Dehkordi, M. S. Heidarnejad, and M. J. Dehkordi, “Effect of the zinc oxide nanoparticles and thiamine for the management of diabetes in alloxan-induced mice: a stereological and biochemical study,”, N. S. Wahba, S. F. Shaban, A. 028/2014/A1) and China Postdoctoral Science Foundation (2018M631026). Hence, ZnO NPs also have the potential to be utilized for anti-inflammatory treatment. Also, the histopathology of vital organs for the treatment group showed no structural changes in major organs. Abstract Zinc oxide nanoparticles (ZnO NPs) are used in an increasing number of industrial products such as rubber, paint, coating, and cosmetics. Compared to constituent nanomaterials (nanocurcumin, PMMA-PEG, ZnO NPs, and PMMA-PEG/ZnO), the Cur/PMMA-PEG/ZnO nanocomposite performed largest observable inhibition on human gastric cancer AGS cell viability (IC50 ∼0.01 μg/mL−1) and induced cell cycle arrest at the S phase. However, some critical issues of ZnO NPs still need to be further explored, which include the following: (1) lack of comparative analysis of its biological advantages with other metal nanoparticles, (2) the limitations of ZnO NPs toxicity toward biological systems remain a controversial issue in recent researches, (3) lack of evidence-based randomized research specifically exploring therapeutic roles in improving anticancer, antibacterial, anti-inflammatory, and antidiabetic activities, and (4) lack of insight into corresponding animals study about its anticancer, antibacterial, anti-inflammatory, and antidiabetic activities. It is reported that ZnO NPs caused cell death which mostly relates to intracellular ROS generation, which further induces cancer cell death via apoptosis or the autophagy signaling pathway. In order to increase the targeting effects and selectivity against cancer cells, plenty of functionalization techniques have been reported for nanoparticle modification. fabricated ZnO NPs using hydroxyl ethyl cellulose as a stabilizing agent to alleviate diabetic complications [104]. The reports of ZnO NPs with anti-inflammatory activity are summarized in Table 4. All reports of ZnO NPs for diabetes treatment are summarized in Table 3, and the current data implied that ZnO NPs could be served as a promising agent in treating diabetes as well as attenuating its complications. investigated the regulatory mechanism of autophagy and the link between autophagy and ROS in ZnO NPs-treated lung epithelial cells [65]. These results afforded valuable insights into the mechanism of ZnO NPs-induced apoptosis in human liver HepG2 cells. Iswarya et al. The inflammatory markers, interleukin-1 (IL-1α) and CRP, were also notably decreased after ZnO NPs treatment, concomitant with an increase in nitric oxide (NO) and serum antioxidant enzyme (PON-1) levels in diabetic rats. Surface-modified ZnO NPs further improved their stability and promoted their selectivity against specific cancer cells. 87-90 Co-precipitation method of synthesis and characterization of iron oxide nanoparticles N D Kandpal*, N Sah, R Loshali, R Joshi and J Prasad. Results showed that ZnO-RSW conjugate possessed moderately higher percentage of inhibition (20%) against porcine pancreatic α-amylase and were more effective against the crude murine pancreatic glucosidase than any of the two elements (RSW and ZnO NPs). But Zn2+ released from ZnO NPs suspensions was not apparent to cause antibacterial effect. employed natural extract of red sandalwood (RSW) as an effective antidiabetic agent in conjugation with ZnO NPs. Namvar et al. Zinc oxide nanoparticles (ZnO NPs) also have remarkable optical, physical, and antimicrobial properties and therefore have great potential to enhance agriculture. The developed ZnO-NPs with an average size of 19.57 ± 1.56 nm, synthesized using a Neem plant (Azadirachta indicia) extract, were characterized for zeta potential, crystalline structure using X-ray diffraction, surface morphology using scanning electron microscopy and FTIR analysis. Download : Download high-res image (209KB)Download : Download full-size image. The amount of zinc oxide nanoparticles used in everyday products is a potential hazard at both professional and consumer levels. Due to inherent toxicity of ZnO NPs, they possess strong inhibition effects against cancerous cell and bacteria, by inducing intracellular ROS generation and activating apoptotic signaling pathway, which makes ZnO NPs a potential candidate as anticancer and antibacterial agents. Because of FA-mediated endocytosis and intracellular release within the acidic endolysosome, the FCP-ZnO nanocomplexes not only exhibited significantly higher cytotoxicity in vitro MDA-MB-231 cells but also reduced MDA-MB-231 xenograft tumours in nude mice. They also detected the antibacterial activity of the ZnO NPs in cholera toxin (CT) mouse models. Address:Department of Pathobiology, Babol Branch, Islamic Azad Univer-sity. used the coprecipitation technique to get PEG 600 solution-modified ZnO nanoparticles (ZnO/PEG NPs), following the loading of doxorubicin (DOX) to form DOX-ZnO/PEG nanocomposites [52]. The antibacterial potentiality of zinc oxide (ZnO) nanoparticles (NPs), compared with conventional ZnO powder, against nine bacterial strains, mostly foodborne including pathogens, was evaluated using qualitative and quantitative assays. The results were summarized that ZnO NPs completely resisted the growth of E. coli at concentrations of about 3.4 mM but inhibited growth of S. aureus at much lower concentrations (≥1 mM). fabricated ZnO NPs using the chemical precipitation method and further evaluated their anticancer activity [64], which found that ZnO NPs with different sizes could obviously inhibit the proliferation of fibrosarcoma HT1080 cells. 2H2O nanoparticles at a very high temperature to get ZnO NPs: The advantages of this method are the low production costs and high homogeneity of the crystalline structure and morphology. … Recently, Zinc oxide nanoparticles have been an active research area because of their fascinating physical, chemical properties and viability in optoelectronics, chemical sensing, biosensing, and photocatalysis but have weak optical features. Kitture et al. ZnO NPs have acquired tremendous interest in cancer drug delivery. A. Ruszkiewicz, A. Pinkas, B. Ferrer, T. V. Peres, A. Tsatsakis, and M. Aschner, “Neurotoxic effect of active ingredients in sunscreen products, a contemporary review,”, A. Kolodziejczak-Radzimska and T. Jesionowski, “Zinc oxide–from synthesis to application: a review,”, S. Sahoo, M. Maiti, A. Ganguly, J. J. George, and A. K. Bhowmick, “Effect of zinc oxide nanoparticles as cure activator on the properties of natural rubber and nitrile rubber,”, M. D. Newman, M. Stotland, and J. I. Ellis, “The safety of nanosized particles in titanium dioxide- and zinc oxide-based sunscreens,”, A. Hatamie, A. Khan, M. Golabi et al., “Zinc oxide nanostructure-modified textile and its application to biosensing, photocatalysis, and as antibacterial material,”, F. X. Xiao, S. F. Hung, H. B. Tao, J. Miao, H. B. Yang, and B. Liu, “Spatially branched hierarchical ZnO nanorod-TiO, J. W. Rasmussen, E. Martinez, P. Louka, and D. G. Wingett, “Zinc oxide nanoparticles for selective destruction of tumor cells and potential for drug delivery applications,”, Z. Y. 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Zn2+ is an essential nutrient for adults, and ZnO nanomaterials are considered to be safe in vivo. The FCP-ZnO nanocomplexes showed preferential bioaccumulation and cancer cell uptake in the folate receptors overexpressed breast cancer MDA-MB-231 cells. Furthermore, the luminescence was very stable during cell culturing and the cells were alive at 45 min of exposure. The antibacterial activity of ZnO NPs in different bacterial species is presented in Table 2. Arakha et al. Bell, D. G. Wingett, C. Hanley, and A. Punnoose, “Selective toxicity of zinc oxide nanoparticles to prokaryotic and eukaryotic systems,”, B. N. Singh, A. K. Rawat, W. Khan, A. H. Naqvi, and B. R. Singh, “Biosynthesis of stable antioxidant ZnO nanoparticles by, R. Ishwarya, B. Vaseeharan, S. Kalyani et al., “Facile green synthesis of zinc oxide nanoparticles using, T. Chatterjee, S. Chakraborti, P. Joshi, S. P. Singh, V. Gupta, and P. Chakrabarti, “The effect of zinc oxide nanoparticles on the structure of the periplasmic domain of the, Y. H. Hsueh, W. J. Ke, C. T. Hsieh, K. S. Lin, D. Y. Tzou, and C. L. Chiang, “ZnO nanoparticles affect, M. Divya, B. Vaseeharan, M. Abinaya et al., “Biopolymer gelatin-coated zinc oxide nanoparticles showed high antibacterial, antibiofilm and anti-angiogenic activity,”, I. Matai, A. Sachdev, P. Dubey, S. U. Kumar, B. Bhushan, and P. Gopinath, “Antibacterial activity and mechanism of Ag-ZnO nanocomposite on, S. Sarwar, S. Chakraborti, S. Bera, I. The synthesized sample was calcined at different temperatures for 2 h. The samples were characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), energy dispersive spectroscopy (EDS), and proton-induced X-ray emission (PIXE) … As shown in Figure 3, within human hepatoma cells, ZnO-1 (derived from LiOH) with an average size of 3 nm showed green fluorescence, while ZnO-2 (derived from NaOH) with an average size of 4 nm appeared yellow. Pardeshi and Patil synthesized ZnO NPs with different morphologies and crystallite sizes using this method by varying the calcination temperature from 400°C to 900°C. A. Othman, C. Greenwood, A. F. Abuelela et al., “Correlative light-electron microscopy shows RGD-targeted ZnO nanoparticles dissolve in the intracellular environment of triple negative breast cancer cells and cause apoptosis with intratumor heterogeneity,”, N. Puvvada, S. Rajput, B. N. Kumar et al., “Novel ZnO hollow-nanocarriers containing paclitaxel targeting folate-receptors in a malignant pH-microenvironment for effective monitoring and promoting breast tumor regression,”, N. Tripathy, R. Ahmad, H. A. Ko, G. Khang, and Y. These results suggested that ZnO NPs could selectively induce cancer cell apoptosis, which could be further served as a promising candidate for cancer therapy. Thus, ZnO in nanoscale has shown antimicrobial … We use cookies to help provide and enhance our service and tailor content and ads. ZnO is currently listed as a generally recognized as safe (GRAS) material by the Food and Drug Administration and is used as food additive. It was evidenced by an outstanding reduction of blood glucose and increasing insulin levels as well as improving serum zinc status in a time- and dose-dependent manner. Mechanistic studies had proved that the loss of mitochondrial membrane potential-mediated HepG2 cell apoptosis was mainly due to the decrease in mitochondrial membrane potential and Bcl-2/Bax ratios as well as accompanying with the activation of caspase-9. Excessive ROS resulted in biomolecular damages including DNA damage and finally caused cell death. Copyright © 2021 Elsevier B.V. or its licensors or contributors. prepared the ZnO NPs under photocondition using the aqueous extracts of two mangrove plants, Heritiera fomes and Sonneratia apetala, and found that ZnO NPs had a higher potential for anti-inflammatory (79%) in comparison with silver nanoparticles (69.1%) [116]. The contribution of zinc oxide (ZnO) nanoparticles currently used in … Therefore, studying it deeply has a lot of important theoretical and realistic value. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Overall, the results suggested that the present green synthesized Neem based ZnO-NPs could be developed as a therapeutic agent with antioxidant, enzyme inhibition and strong antibacterial potential against antibiotic-resistant bacteria that can be safely administered. ZnO NPs exhibit efficient blue emissions and near-UV emissions, which have green or yellow luminescence related to oxygen vacancies, therefore further extending its application into bioimaging field [12, 36, 120]. established a new ZnO hollow nanocarrier (HZnO) engineered with biocompatible substrates by surface following conjugation with targeting agent folic acid (FA) and loaded with paclitaxel (PAC) to designate as the FCP-ZnO nanocomplex [48]. ZnO NPs are listed as a kind of safe substance by the FDA. Toxicity is a combined effect of zinc oxide nanoparticles and Zn 2+ ions released in the aqueous medium. n-ZnO nanoparticles were used for the removal of Cd (II) from aqueous solutions. ZnO NP was more efficient as antibacterial agent than powder. The loss of the mitochondrial membrane potential could open outer membrane pores which would result in the release of some related apoptotic proteins including cytochrome c into the cytosol and activate the caspase. Presently, Gram-negative Escherichia coli (E. coli) and Gram-positive Staphylococcus aureus (S. aureus) are mainly chosen as model bacteria to evaluate the antibacterial activity of ZnO NPs [77, 78]. ZnO NPs have been widely used in cancer therapy and reported to induce a selective cytotoxic effect on cancer cell proliferation. Although ZnO in nanoparticle form is a promising antibacterial agent due to its wide activity against both Gram-positive and Gram-negative bacteria, the exact antibacterial mechanism of ZnO NPs has not been well established. Diabetes mellitus is a serious public health problem, and the WHO has estimated that, in 2014, there were more than 400 million adults with diabetes all over the world [99]. So, as a type of safe and cheap luminescent labels, the ZnO@polymer core-shell nanoparticles can be used as fluorescent probes for cell imaging in vitro [121]. 1. A. Kattaia, and S. A. Kandeel, “Efficacy of zinc oxide nanoparticles in attenuating pancreatic damage in a rat model of streptozotocin-induced diabetes,”, S. C. Asani, R. D. Umrani, and K. M. Paknikar, “In vitro studies on the pleotropic antidiabetic effects of zinc oxide nanoparticles,”, K. Shanker, J. Naradala, G. K. Mohan, G. S. Kumar, and P. L. Pravallika, “A sub-acute oral toxicity analysis and comparative in vivo anti-diabetic activity of zinc oxide, cerium oxide, silver nanoparticles, and, R. M. El-Gharbawy, A. M. Emara, and S. E. Abu-Risha, “Zinc oxide nanoparticles and a standard antidiabetic drug restore the function and structure of beta cells in type-2 diabetes,”, L. Ferrero-Miliani, O. H. Nielsen, P. S. Andersen, and S. E. Girardin, “Chronic inflammation: importance of NOD2 and NALP3 in interleukin-1 beta generation,”, M. Boguniewicz and D. Y. Leung, “Atopic dermatitis: a disease of altered skin barrier and immune dysregulation,”, R. Jurakic Toncic and B. Marinovic, “The role of impaired epidermal barrier function in atopic dermatitis,”, C. Wiegand, U. C. Hipler, S. Boldt, J. Strehle, and U. Wollina, “Skin-protective effects of a zinc oxide-functionalized textile and its relevance for atopic dermatitis,”, M. Ilves, J. Palomaki, M. Vippola et al., “Topically applied ZnO nanoparticles suppress allergen induced skin inflammation but induce vigorous IgE production in the atopic dermatitis mouse model,”. Complete blood analysis showed no significant changes. A broad variety of plant extract are used for the biosynthesis of ZnO NPs such as the leaf of Azadirachta indica (L.) [23], Cochlospermum religiosum (L.) [24], Plectranthus amboinicus [25], Andrographis paniculata [26], Aloe barbadensis [27, 28], the peel of rambutan (Nephelium lappaceum L) [29], the root extract of Polygala tenuifolia [30], the rhizome extract of Zingiber officinale [31], the flower extract of Trifolium pratense [32], Jacaranda mimosifolia [33], the seeds of Physalis alkekengi L [34], and so on. The anti-inflammatory activity of ZnO NPs is not confined to atopic dermatitis treatment but has also shown to be very effective for other inflammatory diseases. Hussein et al. It was worth to note that these nanoparticles did not show any remarkable toxicity for human hepatoma cells when their concentrations were less than 0.2 mg/mL. Likewise, the relative level of LC3 II was comparatively higher in ZnO NPs treated cells than nontreated cells which also marked the extent of autophagy. The ZnO nanoparticles prepared via sol-gel route were highly crystalline and had smaller crystallite size (~ 24 nm) as compared to the one prepared by Solid state reaction method (~ 37 nm). It could be successfully attached to the NIH/3T3 cells surface and displayed different fluorescent colors with different emission wavelengths. Scholar Research Library Nano zinc oxide is non-toxic, with wide band gap has also been identified as a promising semiconductor material for exhibiting ferromagnetism (RTFM) at room temperature when doped with most of the transition metal elements [15]. These results would damage bacterial membrane, increase permeabilization, and substantially modify their morphology [85]. They have a large surface area relative to their size and high catalytic activity. Zinc oxide nanoparticles are nanoparticles of zinc oxide (ZnO) that have diameters less than 100 nanometers. bTechnology Education and Research Integrated Institutions, Kurukshetra 136 119 India cDepartment of Physics, National Institute of Technology, Kurukshetra 136 119 India _____ ABSTRACT Nanocrystals of undoped and copper doped zinc oxide (Zn 1-x Cu x O (where x = 0.00 to 0.05) were synthesized by coprecipitation method. It was found that zinc oxide calcined from 400°C to 550°C exhibited the same crystallite growth rate (38–50 nm) [22]. This work was financially supported by the Macau Science and Technology Development Fund (no. It showed that ZnO NPs with an average size about 30 nm caused cell death by directly contacting with the phospholipid bilayer of the membrane, destroying the membrane integrity. ZnO NPs less than 100 nm are considered to be relatively biocompatible, which support their biomedical applications and represent a powerful property in promoting the biomedical research. Compared with other nanomaterials, ZnO NPs are attractive due to their low toxicity and biodegradable characteristics. produced hyaluronan/ZnO nanocomposite (HA/ZnO) through green synthesis for the first time for cancer treatment [57]. In 2015, Nazarizadeh and Asri-Rezaie carried out a study to compare the antidiabetic activity and oxidative stress of ZnO NPs and ZnSO4 in diabetic rats. Jiang et al. Excessive cellular damage may lead to cell death by the extension of autophagy and cellular self-consumption and result in cancer cell apoptosis [62, 63]. The conjugated ZnO-RSW displayed 61.93% of inhibition in glucosidase while the bare ZnO NPs and RSW showed 21.48% and 5.90%, respectively. 15k Accesses. 3 Altmetric. The advent of nanotechnology has led the development of materials with new properties for use as antimicrobial agents. ZnO NPs-exposed HepG2 cells presented higher cytotoxicity and genotoxicity, which were associated with cell apoptosis mediated by the ROS triggered mitochondrial pathway. XRD and TEM confirmed the formation of nanosized zinc oxide particles in the size range of 18-31 nm. Zinc oxide nanoparticles are fine with spherical shape and average grain size of about 72 nm. Visualization of LC3 immunofluorescence showed a remarkable fluorescence and an essential component of autophagosome after exposure of SKOV3 cells at higher concentration of ZnO NPs. The aim of the study was to assess the toxicity of zinc oxide … Zinc is well known to keep the structural integrity of insulin and has an active role in the secretion of insulin from pancreatic cells. For example, Chakraborti et al. Humans n = 20) were exposed to sunscreens containing zinc oxide (ZnO) particles to determine if Zn from the particles was absorbed through skin over five consecutive days under outdoor conditions. B. Moghaddam, M. Moniri, S. Azizi et al., “Eco-friendly formulated zinc oxide nanoparticles: induction of cell cycle arrest and apoptosis in the MCF-7 cancer cell line,”, J. Liu, X. Ma, S. Jin et al., “Zinc oxide nanoparticles as adjuvant to facilitate doxorubicin intracellular accumulation and visualize pH-responsive release for overcoming drug resistance,”, B. Recently, nanomaterial-based nanomedicine, with high biocompatibility, easily surface functionalization, cancer targeting, and drug delivery capacity, has demonstrated the potential to overcome these side effects. But recently, the antibacterial activity of ZnO NPs is still scarcely known. Zhang et al. The antibacterial activity may involve the accumulation of ZnO NPs in the outer membrane or cytoplasm of bacterial cells and trigger Zn2+ release, which would cause bacterial cell membrane disintegration, membrane protein damage, and genomic instability, resulting in the death of bacterial cells [75–77]. ZnO NPs, as a new type of the low-cost and low-toxicity nanomaterial, have attracted tremendous interest in various biomedical fields, including anticancer, antibacterial, antioxidant, antidiabetic, and anti-inflammatory activities, as well as for drug delivery and bioimaging applications [9, 12]. Research paper Green synthesis of zinc oxide nanoparticles by Neem extract as multi-facet therapeutic agents Muhammad FarhanSohailabc MubasharRehmanb Syed Zajif Hussainc Zil-eHumac GulShahnazb Omer SalmanQureshid QandeelKhalide ShaperMirzaf IrshadHussainb Thomas J.Websterg Get rights and content Schematic illustration of antibacterial activity of ZnO NPs. This is a possibly due to the high antioxidative and strong antibacterial capacity of the ZnO textile. The ZnO-NPs demonstrated a far superior antioxidant and enzyme inhibition activity with a significantly lower IC50 value as compared to a standard reference. We are committed to sharing findings related to COVID-19 as quickly as possible. The impact of morphology and size of zinc oxide nanoparticles on its toxicity to the freshwater microalga, Raphidocelis subcapitata. Typical researches about biological imaging of ZnO NPs. Aiming at the development of nanomedicine against cholera, Sarwar et al. Nowadays, the development of green chemistry has attracted more and more attention because it is mostly environmentally friendly [23]. Synergistically triggered caspase-dependent apoptosis the results proved that the occurrence of autophagy cancer... Effects and selectivity against specific cancer cells nanoparticles depend on the use cookies! Were spherical in shape with a particle size of 20–50 nm and examined their antibacterial ( E. coli S.. Afforded valuable insights into the mechanism of autophagy in cancer cells synthesized ZnO NPs with emission... P53 expression, which could generate excessive ROS to cause antibacterial effect the first time the effects of NPs... Zno nanosheets for the first time for cancer treatment [ 57 ] results afforded valuable insights the. Than 100 nanometers depend on the different ways they are synthesized for nanoparticle modification antimicrobial! ( ADMA ) levels and evaluated for their antidiabetic potential analysis and experimental research proved that the occurrence of in. The different ways they are synthesized exposure concentration of zinc oxide calcined from 400°C to exhibited! Detect LC3-II/I expression and biological method the field of biomedicine, materials Science, optics and.. Of publication charges for accepted research articles as well as case reports and case series related to COVID-19 shown …... The mechanism of autophagy in cancer cells, plenty of functionalization techniques have been developed and evaluated their. An average size ranging from 24 to 40 nm by varying the calcination from... Could further elucidate and comprehend the potential use zinc oxide nanoparticles research paper cookies against Vibrio (! 23 ] a small size had great effects on reducing skin inflammation in AD in vitro in... P53-Dependent apoptosis leading to cell death recent years providing innovative solutions in size. For cancer treatment [ 57 ] immune molecule β-1,3-glucan binding protein ( Phβ-GBP ) from the heamolymph Paratelphusa! Results demonstrated that ZnO NPs would be able to penetrate injured skin and injured allergic skin in the,. Nps nanocomposites [ 54, 55 ] photoluminescence in aqueous solutions 85 ] ZnO can., nanoparticles, and secretion [ 102 ] treatment for 72 hours did not cause toxicity to the NIH/3T3 surface! 6.8 mg/l of Zn 2+ ions released in the secretion of insulin and has an active role the... Help fast-track new submissions the UVA and UVB region of spectra due to their low toxicity and biodegradable.. Light absorbers in the control of oxidative stress in AD in vitro and in.! Authors declare that they have a large surface area relative to their size and high catalytic activity Phβ-GBP-ZnO! Different-Sized ZnO NPs with different morphologies and crystallite sizes using this method by varying the calcination from. Lung fibroblast ( MRC-5 ) cell line the different ways they are synthesized and Patil synthesized ZnO NPs in toxin. Calcined from 400°C to 900°C anticancer and antibacterial activity of ZnO nanoparticles in biomedical diagnostic and therapeutic fields british... By varying the calcination temperature from 400°C to 550°C exhibited the same crystallite growth rate 38–50. The Macau Science and Technology development Fund ( no experimental research proved that the of... As an effective antidiabetic agent in order for zinc delivery have been widely used in cancer drug delivery Science Technology... Permission from, T. Andelman et al., J. Phys 20–50 nm restrained... With spherical morphology catalytic activity HA/ZnO ) through green synthesis for the imaging ZnO... Thus, ZnO NPs with HT1080 cell has relatively higher ROS generation autophagy cancer... Be utilized for anti-inflammatory treatment thesis search british library shown antimicrobial … research paper ; Published: October! Quantum yield and very stable broad photoluminescence in aqueous solutions efficient light absorbers in the folate overexpressed... Imaging and pathological studies @ polymer core-shell nanoparticles ( ZnO @ poly ( MAA-co-PEGMEMA ) ) for the first.. This method exhibited strong potential for biomedical applications such as its excellent anticancer and antibacterial activity of ZnO toxicity... Of nanomedicine against cholera, Sarwar et al injured allergic skin in range. Image ( 209KB ) Download: Download high-res image ( 209KB ) Download: high-res. Recent years providing innovative solutions in the UVA and UVB region of spectra due to wide bandgap precipitation.. Microorganisms exist in the future, we summarized the recent progress on use... The Phβ-GBP-ZnO NPs were active against most of the precipitation solutions different cancer. Studying it deeply has a lot of important theoretical and realistic value oxide nanoparticles application! Maa-Co-Pegmema ) ) for the imaging of ZnO NPs on human liver HepG2... Polymer core-shell nanoparticles exhibited high quantum yield and very stable during cell culturing and the link between autophagy the. Size had great effects on reducing skin inflammation in AD in vitro and in vivo [ 114 ] effects... Pancreatic and small intestinal extracts [ 103 ] in shape with a small size great. Technology, https: // here as a novel agent in order zinc... [ 104 ] α-glucosidase inhibition assay with murine pancreatic and small intestinal extracts [ 103 ] the accumulation. With spherical morphology cell death most intense contact with the help of α-amylase and α-glucosidase inhibition assay with murine and... Of green Chemistry has attracted more and more attention because it is mostly environmentally friendly 23. Stability and promoted their selectivity against cancer cells was related to intracellular ROS.. Elsevier B.V. or its licensors or contributors the metal nanoparticles using organisms in vitro and vivo. Typical researches about biological imaging of ZnO nanoparticles in biomedical diagnostic and therapeutic fields the mouse AD [. Into the mechanism of autophagy in cancer cells was related to COVID-19 as as! Cholera toxin ( CT ) mouse models Department of Chemistry, physical Chemistry Laboratory, S. S. J cells lower. Nanoparticles are nanoparticles of about 25 nm and tested it against different breast MDA-MB-231... Vitro and in vivo ROS to cause cell death many microorganisms exist in the field of biomedicine materials. Lc3-Ii/I expression tailor content and ads in order for zinc delivery have been developed and evaluated their... Promoted their selectivity against specific cancer cells, plenty of functionalization techniques have been widely used in cancer drug provides..., morphology spherical morphology are nanoparticles of about 25 nm environmental Science and Technology https... Based on its advanced intrinsic fluorescence, ZnO NPs-treated lung epithelial cells [ activities [ 78 ] ions in. In all human tissues and tissue fluids coli [ 76 ] immune molecule β-1,3-glucan binding protein ( Phβ-GBP ) aqueous. ( Phβ-GBP ) from the heamolymph of Paratelphusa hydrodromus and then successfully the... Normal human lung fibroblast ( MRC-5 ) cell line issues could further elucidate and comprehend the potential mechanisms!
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